CD51 anticorps

N° du produit ABIN2624341

Cet anticorps anti-CD51 est un anticorps Souris Monoclonal détectant CD51 dans IHC, FACS, IP, ELISA et IHC (fro). Adapté pour Humain.

Aperçu rapide pour CD51 anticorps (ABIN2624341)

Antigène: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD51 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: NKI-M7 (former AMF7)

Détail du produit anti-CD51 anticorps

Specificité: T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kD) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kD respectively. NKI-M7 reacts with cultured melanomas melanomas in frozen sections. The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. NKI-M7 blocks fibronectin-induced chemotactic motility and chemokinesis of melanoma cells. In addition to their membrane localization, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.

Purification: Purified

Immunogène: NKI-M7 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cultured melanoma cells derived from a Human melanoma metastasis.

Type of Immunogen: Cells

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, Flo, IHC, IHC-Fr, IP

Usage: CD51 (Cluster of Differentiation 51), known as vitronectin receptor alpha chain, or integrin alpha V is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin beta 1 (CD29), beta 3 (CD61), beta 5, beta 6, or beta 8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its beta chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C, or in small aliquots at -20°C.

Détails sur CD51

Antigène: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Autre désignation: ITGAV/Integrin alpha V/CD51

Sujet: Name/Gene ID: ITGAV
Family: Integrin

Synonyms: ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR

ID gène: 3685

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex